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L-Citrullin 180 caps

L-Citrullin 180 caps

  • Best choice NO-Booster
  • Japanese top quality
  • Pure form!
  • Free of synthetic DL-malate
Quality tested annually by independent laboratory.
View the laboratory analysis (.pdf)
2 times more effective than arginine


180 capsules of 750 mg Japanese L-citrulline.


Take 2 to 6 capsules (1500 to 4500 mg of L-citrulline) per day.

If you choose a higher dosage than 2 capsules per day, spread the intake over the day. Take the capsules with some water during a meal or on an empty stomach. Build up the dosage gradually over several weeks. Do not exceed the maximum dose of 6 capsules a day.
Dietary supplements are no subsitute for a balanced diet.


- L-citrulline
- Bovine gelatin (capsule)
- Rice starch
- Magnesium stearate

The amino acid L-citrulline promotes the production of nitric oxide (better known as nitrogen oxide, or NO) in the human body. Due to the stimulating or 'boosting' effect on NO, L-citrulline has the following effects: 

  • Stimulates fat breakdown
  • Stimulates muscle growth
  • Promotes detoxification of ammonia (protein metabolism)
  • Reduces fatigue during and after exercise

A container wth 180 capsules of L-Citrulline (total 135 grams) contains the same amount of NO stimulating L-citrulline as 237 grams of citrulline malate. L-citrulline is also two times more effective than the other known NO-booster: L-arginine.
The L-citrulline in this supplement is produced by the leading Japanese manufacturer Kyowa Hakko.

NO, the good radical

NO (nitric oxide) is a pretty radical and reactive molecule. Free radicals have been seen as a negative aspectfor the human body for a long time. They would cause the body to 'rust'. But the body needs some radicals more than others. For instance they are essential for achieving an exercise effect. They help the body to adjust.
Effect of the NO radical in the body:

  • Promotes the growth of muscle cells
  • Promotes the absorption of nutrients in the muscles
  • Activates satellite cells (muscle stem cells)
  • Helps with the repair of muscle cells
  • Activates the cGMP substance, causing muscle cells to burn more fat and sugars
  • Activates the immune system
  • Causes vasodilation (improves blood flow to the muscle/pumping)
  • Stimulates wound healing

Radicals versus anti-oxidants

Anti-oxidants, such as vitamin C and vitamin E, deactivate the free radicals. According to research, high dosages of antioxidants can therefore hold back the training progress of young athletes.

As mentioned earlier, free radicals can cause the body to 'rust'. Technically speaking, the rusting process is referred to as 'oxidative damage'. It's been researched if the use of a NO-Booster in the form of L-citrulline also contributes to extra oxidative damage. It turns out that's not the case! Source: PubMed. L-citrulline does not make you 'rust'!

L-citrulline versus L-arginine

It has been determined that various substances support the production of NO in our body. The best-known NO-Boosting Supplement is an amino acid called arginine. Arginine is being studied by scientists for years. In 2010 an article came out where the following was concluded, in a nutshell:

There is growing evidence that L-arginine reduces obesity in animals and humans. Recent research suggests that L-arginine supplementstimulates the growth of mitochondria (tiny energy factories of the cell) and also promotes the development of brown adipose tissue (which is good news because brown fat makes you lose weight due to its high energy consumption. L-arginine is a promising, safe and cost-effective way of reducing body fat, and increase muscle mass and improve the metabolism of humans and animals. (roughly summarized and translated from: Beneficial effects of L-arginine on Reducing obesity: potential mechanisms and Important Implications for human health).

But what arginine can do, citrulline can do better! Citrulline is converted into arginine in the human body. Citrulline functions as a kind of arginine depot; it ensures a steady production of arginine in the body. The steady release may be beneficial to muscle growth and fat breakdown!
A disadvantage of arginine is that it is already broken down to a large extent by the liver shortly after ingestion. The degraded arginine is then lost for our purpose. Citrulline, however, passes the liver unobstructed.

Lastly, another disadvantage of arginine is that it can quickly lead to diarrhea. Citrulline is actually very mild and hardly irritates the intestines.

L-citrulline versus citrulline malate

Citrulline is mainly sold in the form of citrulline malate. A large part of the effects of citrulline malate are due to citrulline. Though also malate has probably some performance-enhancing effects. Particularly it has an impact on the stamina of athletes.

L-Malate is another name for malic acid. However, there is also something called a D-malate. This is a synthetic unnatural kind of malate. Fifty percent of the malate that can be found in virtually all supplements is D-malate. It is our belief that D-malate does not belong in our body.

If you still want the benefits of malate on your health, then you have a few options:

- Take our pure citrulline with one or two glasses of apple juice (1 g L-malate per glass).
- Take citrulline malate from a reputable provider (like Stimol from Biocodex).


In the mid-term a lot of research has been done regarding NO-Boosters. It was concluded that it's pretty safe to use. No studies have been done regarding the long term effect of enhancing the NO-response.

Because the amino acid arginine (just like citrulline) is promising for the treatment of obesity, an estimate has been made over its long-term safety. Based on arginine administration in animals it turned out that negative long term effects cannot be expected. Scientists suspect that a person weighing 70kg could use a daily dose of 15 grams of arginine without any negative consequences. Source: PubMed.

We would like to point out that high doses of arginine (at least in the short term) led to stomach problems in many people. Think of diarrhea and stomach pain. A staggered intake over the course of the day may reduce this problem. It's a better idea to use citrulline. Citrulline converts to arginine and is more efficient in raising the arginine concentration level than arginine itself, as has been mentioned above.

Absolutely the highest purity by Japanese top quality standards!

The L-citrulline which Power Supplements uses for this dietary supplement is produced by Kyowa Hakko. This Japanese company specializes in the production of amino acids for food supplements and pharmaceutical applications. Kyowa Hakko uses sophisticated fermentation technology. Aside from production the company also focuses on research.

You won't find a purer L-citrulline supplement around.

Despite the high quality it's still offered at a low price

Power Supplements offers this expensive Japanese quality L-citrulline at a very low price. The price is comparable to many low-Citrulline Malate supplements on the internet. But with Power Supplements you can be sure that the low prices aren't because of the cheap ingredients produced under poorly inspected conditions.

Contraindications and warnings

Do not use in combination with cardiovascular medications and viagra, when you suffer from liver disease, during pregnancy or breastfeeding. People with a (latent) cold sore should only use L-citrulline in combination with the amino acid L-lysine. The use of synthetic citrulline-DL-malate could cause palpitations. If you notice these or any other side effects when using pure L-citrulline, please contact Power Supplements.

Quality tested annually by independent laboratory.
View the laboratory analysis (.pdf)

See also
L-Citrulline 400g
L-Citrulline 400g